Ziprasidone augmentation for anxious depression

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Adjunctive Ziprasidone for Depression

Background: Antipsychotics are common adjunctive treatments for residual symptoms in major depressive disorder. Ziprasidone has pharmacological features that differ from other antipsychotics approved for antidepressant augmentation (i.e., aripiprazole, olanzapine, quetiapine) and was shown in an open-label study to be an effective adjunct in treatment-resistant depression.2 The present study ap...

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Clinical Interventions for Late-Life Anxious Depression

Anxiety symptoms are frequently present in patients with late-life depression. The designation "anxious depression" has been used to describe major depressive disorder (MDD) accompanied by clinically significant but subsyndromal anxiety symptoms. MDD may also present comorbid with diagnosable anxiety disorders, although this presentation is less common in late life. Diagnosis of anxious depress...

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A comparison of structural connectivity in anxious depression versus non-anxious depression.

BACKGROUND Major depressive disorder (MDD) and anxiety disorders are highly co-morbid. Research has shown conflicting evidence for white matter alteration and amygdala volume reduction in mood and anxiety disorders. To date, no studies have examined differences in structural connectivity between anxious depressed and non-anxious depressed individuals. This study compared fractional anisotropy (...

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Defining anxious depression: going beyond comorbidity.

OBJECTIVE Since publication of the DSM-IV, there remains a group of patients with depression and anxiety symptoms who are not well classified. We therefore wanted to determine more accurately the type of patients best described by the term "anxious depression." We also wanted to review the literature to assess the most appropriate treatment(s) for these patients. METHOD We surveyed the medica...

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Efficacy of ziprasidone monotherapy in patients with anxious depression: a 12-week, randomized, double-blind, placebo-controlled, sequential-parallel comparison trial.

UNLABELLED Anxious depression, defined as major depressive disorder (MDD) accompanied by high levels of anxiety, seems to be difficult to treat with traditional antidepressant monotherapy. The purpose of this study was to assess the efficacy of ziprasidone monotherapy in patients with anxious depression versus non-anxious depression. One hundred and twenty outpatients were enrolled in a 12-week...

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ژورنال

عنوان ژورنال: International Clinical Psychopharmacology

سال: 2016

ISSN: 0268-1315

DOI: 10.1097/yic.0000000000000133